2,3-Dihydro-1H-pyrido[3,4-b][1,4]oxazine → HCID 44610275, 화합물

반응식

[NH:1]1[CH2:6][CH2:5][O:4][C:3]2[CH:7]=[N:8][CH:9]=[CH:10][C:2]1=2.[Br:11][C:12]1[CH:13]=[C:14]([CH:18]=[C:19]([Br:23])[C:20]=1[O:21][CH3:22])[C:15](Cl)=[O:16]>>[Br:11][C:12]1[CH:13]=[C:14]([C:15]([N:1]2[CH2:6][CH2:5][O:4][C:3]3[CH:7]=[N:8][CH:9]=[CH:10][C:2]2=3)=[O:16])[CH:18]=[C:19]([Br:23])[C:20]=1[O:21][CH3:22]

참가 물질

반응물 2

HCID 219615362,3-Dihydro-1H-pyrido[3,4-b][1,4]oxazine

HCID 337796303,5-Dibromo-4-methoxybenzoyl chloride

생성물 1

HCID 44610275HCID 44610275, 화합물

실험 절차

By the same method as in the step d) of Example 2, 2,3-dihydro-1H-pyrido[3,4-b][1,4]-oxazine (180 mg, 0.587 mmol) and 3,5-dibromo-4-methoxy-benzoyl chloride (193 mg, 0.587 mmol) were reacted to obtain the target compound 5, (3,5-dibromo-4-methoxy-phenyl)-(2,3-dihydro-pyrido[3,4-b][1,4]oxazin-1-yl)-methanone, as white solid (85 mg, 34%).

출처 및 근거

ORD 기록: ord-719ba20ef2304f3b8e9e7bd9e1b6ed85
출처 데이터셋: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08394792B2

반응 노트

불러오는 중…