tert-butyl 3-methoxy-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-5-ylcarbamate → 3-Methoxy-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-5-amine

HRID 1943891노트

반응식

HRID 1943891 반응식
[CH3:1][O:2][C:3]1[C:11]2[C:6](=[N:7][CH:8]=[C:9]([NH:12]C(=O)OC(C)(C)C)[CH:10]=2)[N:5]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=2)[N:4]=1>FC(F)(F)C(O)=O>[CH3:1][O:2][C:3]1[C:11]2[C:6](=[N:7][CH:8]=[C:9]([NH2:12])[CH:10]=2)[N:5]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=2)[N:4]=1

참가 물질

3

반응물 1

HCID 67089104tert-butyl 3-methoxy-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-5-ylcarbamate

생성물 1

HCID 670888713-Methoxy-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-5-amine

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

tert-Butyl 3-methoxy-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-5-ylcarbamate (0.0159 g, 0.0414 mmol) was dissolved in trifluoroacetic acid (2.0 mL) and stirred at room temperature for 1 hour. The reaction mixture was concentrated to provide 3-methoxy-1 (4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-5-amine, which was used directly in the next step.

후처리

  1. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-4ee88d0dd2594be99c8c329bcb7208e5
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08394795B2

반응 노트

불러오는 중…