Sodium Methoxide → 7-Bromo-2-methoxymethylimidazo[1,2-a]pyridine

HRID 1943997노트

반응식

HRID 1943997 반응식
[Br:1][C:2]1[CH:7]=[CH:6][N:5]2[CH:8]=[C:9]([CH2:11]Cl)[N:10]=[C:4]2[CH:3]=1.[CH3:13][O-:14].[Na+]>CO>[Br:1][C:2]1[CH:7]=[CH:6][N:5]2[CH:8]=[C:9]([CH2:11][O:14][CH3:13])[N:10]=[C:4]2[CH:3]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 441183127-Bromo-2-chloromethylimidazo[1,2-a]pyridine

생성물 1

HCID 581039787-Bromo-2-methoxymethylimidazo[1,2-a]pyridine수율 33.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 81 mg (0.33 mmol) of 7-bromo-2-chloromethylimidazo[1,2-a]pyridine, prepared according to the protocol described in step 8.3, in 3 mL of anhydrous methanol, stirred at room temperature under an inert atmosphere, are added 35 mg (0.99 mmol) of sodium methoxide. The reaction mixture is stirred at 100° C. for 4 hours. After this time, the reaction medium, cooled to room temperature, is concentrated under reduced pressure, diluted with 10 mL of chloroform and then washed with 10 mL of saturated aqueous NaCl solution. The crude reaction product obtained after evaporating off the solvent under reduced pressure is purified by chromatography on a column of silica gel, eluting with a mixture of dichloromethane and methanol. 27 mg of the expected product are thus obtained.

후처리

  1. stirringThe reaction mixture is stirred at 100° C. for 4 hours
  2. temperatureAfter this time, the reaction medium, cooled to room temperature
  3. concentrationis concentrated under reduced pressure
  4. additiondiluted with 10 mL of chloroform
  5. washwashed with 10 mL of saturated aqueous NaCl solution
  6. customThe crude reaction product
  7. customobtained
  8. customafter evaporating off the solvent under reduced pressure
  9. customis purified by chromatography on a column of silica gel
  10. washeluting with a mixture of dichloromethane and methanol

출처 및 근거

ORD 기록
ord-c40d237243de4f9cac7b1f86d590f0ca
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08394820B2

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