Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetate → 4-(4-(2-Hydroxyphenyl)thiophenyl)butyric acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetate | HCID 175 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Phenol, o-mercapto-(6CI,7CI,8CI) | HCID 70718 | — |
| 반응물 | 4-(p-Iodophenyl)butyric acid | HCID 4645427 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-(4-(2-Hydroxyphenyl)thiophenyl)butyric acid | HCID 68494380 | — |
반응 단계
A solution of 4-(4-iodophenyl)butyric acid (0.86M) and dimethylformamide was treated with 2 eq of potassium carbonate, 1.5 eq of 2-hydroxythiophenol and a catalytic amount of cuperic acetate (0.01 eq). The reaction mixture was refluxed for 18 hr, cooled to 25 C, acidified with aqueous acid and extracted with ethyl acetate. The organic phase was concentrated. The residue was purified by flash chromatography using ethyl acetate/hexane as eluant to give 4-(4-(2-hydroxyphenyl)thiophenyl)butyric acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07744910B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-e7e01cb1d6b341e290203e4523dd3350 |
| 출처 메모 | uspto-grants-2010_06 |