Potassium Carbonate → 3-(Thiophen-2-ylsulfanyl)thiophene-2-carbaldehyde

HRID 1944408노트

반응식

HRID 1944408 반응식
Cl[C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]=[O:8].C(=O)([O-])[O-].[K+].[K+].[S:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[SH:20]>CN(C)C=O>[S:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[S:20][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]=[O:8]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 5226742-ThiophenethiolHCID 27358253-Chlorothiophene-2-carbaldehyde

생성물 1

HCID 866521863-(Thiophen-2-ylsulfanyl)thiophene-2-carbaldehyde수율 97.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 3-chlorothiophene-2-carbaldehyde (1.0 g), potassium carbonate (2.8 g) and N,N-dimethylformamide (6.8 mL) was treated dropwise with thiophene-2-thiol (0.87 g), and the resulting mixture was stirred at room temperature for 3 hours. The mixture was poured onto water (150 mL) and extracted with diethyl ether. The combined organic extract was washed with saturated aqueous sodium hydrogen carbonate solution and saturated aqueous sodium chloride solution, and then dried over magnesium sulfate. The solvent was removed under reduced pressure to afford the title compound as a red oil (1.5 g).

후처리

  1. additionThe mixture was poured onto water (150 mL)
  2. extractionextracted with diethyl ether
  3. extractionThe combined organic extract
  4. washwas washed with saturated aqueous sodium hydrogen carbonate solution and saturated aqueous sodium chloride solution
  5. dry with materialdried over magnesium sulfate
  6. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-f69c132f935243e8b4ad23356c78f40f
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08394836B2

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