Trifluoroacetic acid → HCID 59264546, 화합물

HRID 1944717노트

반응식

HRID 1944717 반응식
[CH3:1][O:2][CH2:3][CH2:4][C@@H:5]([NH:12]C(=O)OC(C)(C)C)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][O:2][CH2:3][CH2:4][C@H:5]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[NH2:12]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 57791175HCID 57791175, 화합물2회

생성물 1

HCID 59264546HCID 59264546, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(R)-tert-Butyl 3-methoxy-1-phenylpropylcarbamate (Intermediate 61, 78 mg, 0.294 mmol) was dissolved in DCM (4.5 ml) and TFA (0.5 ml) was added. The reaction mixture was stirred for 1 h at room temperature when LCMS indicated that the reaction was complete. The reaction mixture was concentrated in vacuo, and the crude product was taken onto next step without further purification (0.294 mmol). LCMS [M+H]=166

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe crude product was taken onto next step without further purification (0.294 mmol)

출처 및 근거

ORD 기록
ord-d4c43da7970f4d3297495ebb8685d3c2
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08394858B2

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