Dimethylformamide → 4-(1,3-Dioxoisoindolin-2-yl)-1-methylcyclohexanecarbonyl chloride

HRID 1944723노트

반응식

HRID 1944723 반응식
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH:12]1[CH2:17][CH2:16][C:15]([CH3:21])([C:18](O)=[O:19])[CH2:14][CH2:13]1.C(Cl)(=O)C([Cl:25])=O.CN(C=O)C>C(Cl)Cl>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH:12]1[CH2:17][CH2:16][C:15]([CH3:21])([C:18]([Cl:25])=[O:19])[CH2:14][CH2:13]1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 580743564-(1,3-Dioxoisoindolin-2-yl)-1-methylcyclohexanecarboxylic acid2회

생성물 1

HCID 580743734-(1,3-Dioxoisoindolin-2-yl)-1-methylcyclohexanecarbonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-(1,3-Dioxoisoindolin-2-yl)-1-methylcyclohexanecarboxylic acid (Intermediate 74, 220 mg, 0.786 mmol) was dissolved in DCM (5 mL), and oxalyl chloride (146 mg, 0.1 mL, 1.149 mmol) was added slowly, followed by addition of a drop of DMF. The mixture was stirred at room temperature for 20 min, then concentrated under vacuum to provide the product as a yellow solid that was used as is in the next step.

후처리

  1. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-88e9bf4991074e81bb46feb97be08ec8
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08394858B2

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