1-Benzyl-4-((6-((tert-butyldimethylsilyl)oxy)hexyl)oxy)piperidine → HCID 58505168, 화합물

HRID 1944858노트

반응식

HRID 1944858 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[Si:22]([O:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][O:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23]

참가 물질

5

반응물 2

HCID 575169301-Benzyl-4-((6-((tert-butyldimethylsilyl)oxy)hexyl)oxy)piperidineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 58505168HCID 58505168, 화합물수율 98.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Intermediate 22 (157 mg, 0.387 mmol) was dissolved in MeOH (5 mL) then added 10% (w/w) Pd/C (41 mg, 0.0387 mmol). The reaction vessel was attached to 3-way valve with balloon containing hydrogen gas. The vessel was evacuated 3 times then back flushed with hydrogen. The resulting suspension was stirred overnight, filtered, and concentrated to give the title compound (120 mg) as clear oil. The compound was used with no further purification. ES/MS calcd for C17H38NO2Si+ 316.3. Found m/z=316.3 (M+H)+.

후처리

  1. customThe reaction vessel was attached to 3-way valve with balloon
  2. customThe vessel was evacuated 3 times
  3. customthen back flushed with hydrogen
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-3fbf310c0dfe43c58cab7d547eaeb997
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08394829B2

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