6-((4-Bromophenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide → HCID 66988803, 화합물

HRID 1944891노트

반응식

HRID 1944891 반응식
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6](C2C=CC=C(S(C3C=C4C(=C(C)C=3)N=CC(C(N)=O)=C4NC3C=CC=C(OC)C=3)(=O)=O)C=2)=[CH:5][CH:4]=1.Br[C:42]1[CH:47]=[CH:46][C:45]([S:48]([C:51]2[CH:52]=[C:53]3[C:58](=[C:59]([CH3:61])[CH:60]=2)[N:57]=[CH:56][C:55]([C:62]([NH2:64])=[O:63])=[C:54]3[NH:65][C:66]2[CH:71]=[CH:70][CH:69]=[C:68]([O:72][CH3:73])[CH:67]=2)(=[O:50])=[O:49])=[CH:44][CH:43]=1>>[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:42]2[CH:47]=[CH:46][C:45]([S:48]([C:51]3[CH:52]=[C:53]4[C:58](=[C:59]([CH3:61])[CH:60]=3)[N:57]=[CH:56][C:55]([C:62]([NH2:64])=[O:63])=[C:54]4[NH:65][C:66]3[CH:71]=[CH:70][CH:69]=[C:68]([O:72][CH3:73])[CH:67]=3)(=[O:50])=[O:49])=[CH:44][CH:43]=2)=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 669882586-((4-Bromophenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamideHCID 66988923HCID 66988923, 화합물

생성물 1

HCID 66988803HCID 66988803, 화합물수율 77%

실험 절차

The title compound was synthesized in a manner analogous to that described for Intermediate 64, using Intermediate 63 (1.38 mmol) as substrate. The crude product was triturated in 15 mL of ethyl acetate for 10 min. After cooling to room temperature, the suspension was recovered by filtration and washed with ethyl acetate to give the title compound as a yellowish solid (591 mg, 77% for 3 steps). ES/MS calcd. for C31H28N3O5S+ 554.2. Found m/z=554.3 (M+H)+.

후처리

  1. customThe title compound was synthesized in a manner analogous to
  2. customThe crude product was triturated in 15 mL of ethyl acetate for 10 min
  3. filtrationthe suspension was recovered by filtration
  4. washwashed with ethyl acetate

출처 및 근거

ORD 기록
ord-8defdb65aecd4e0d9ffe7946f7300864
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08394829B2

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