6-((4'-(5-Hydroxypentyl)-(1,1'-biphenyl]-4-yl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide → 4-((3-Methoxyphenyl)amino)-8-methyl-6-((4'-(5-oxopentyl)-[1,1'-biphenyl]-4-yl)sulfonyl)quinoline-3-carboxamide
반응식
COC1C=C(NC2C3C(=C(C)C=C(S(C4C=CC=C(C(=O)NC5C=CC(C6C=CC(CCCC=O)=CC=6)=CC=5)C=4)(=O)=O)C=3)N=CC=2C(N)=O)C=CC=1.[OH:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][C:59]1[CH:64]=[CH:63][C:62]([C:65]2[CH:70]=[CH:69][C:68]([S:71]([C:74]3[CH:75]=[C:76]4[C:81](=[C:82]([CH3:84])[CH:83]=3)[N:80]=[CH:79][C:78]([C:85]([NH2:87])=[O:86])=[C:77]4[NH:88][C:89]3[CH:94]=[CH:93][CH:92]=[C:91]([O:95][CH3:96])[CH:90]=3)(=[O:73])=[O:72])=[CH:67][CH:66]=2)=[CH:61][CH:60]=1>>[CH3:96][O:95][C:91]1[CH:90]=[C:89]([NH:88][C:77]2[C:76]3[C:81](=[C:82]([CH3:84])[CH:83]=[C:74]([S:71]([C:68]4[CH:67]=[CH:66][C:65]([C:62]5[CH:63]=[CH:64][C:59]([CH2:58][CH2:57][CH2:56][CH2:55][CH:54]=[O:53])=[CH:60][CH:61]=5)=[CH:70][CH:69]=4)(=[O:72])=[O:73])[CH:75]=3)[N:80]=[CH:79][C:78]=2[C:85]([NH2:87])=[O:86])[CH:94]=[CH:93][CH:92]=1참가 물질
3
반응물 2
생성물 1
실험 절차
The title compound was synthesized in a manner analogous to that described for Intermediate 124, using Intermediate 68 as substrate. ES/MS calcd. for C35H34N3O5S+ 608.2. Found m/z=608.3 (M+H)+.