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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Acetic Acid → (R)-6-[[3-[[8-[[2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

HRID 1944975
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HRID 1944975 반응식
CCCC[N+](CCCC)(CCCC)CCCC.[F-].[Si]([O:26][C@H:27]([C:73]1[CH:82]=[CH:81][C:80]([OH:83])=[C:79]2[C:74]=1[CH:75]=[CH:76][C:77](=[O:84])[NH:78]2)[CH2:28][NH:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][NH:38][C:39]([C:41]1[CH:42]=[C:43]([S:47]([C:50]2[CH:51]=[C:52]3[C:57](=[C:58]([CH3:60])[CH:59]=2)[N:56]=[CH:55][C:54]([C:61]([NH2:63])=[O:62])=[C:53]3[NH:64][C:65]2[CH:70]=[CH:69][CH:68]=[C:67]([O:71][CH3:72])[CH:66]=2)(=[O:49])=[O:48])[CH:44]=[CH:45][CH:46]=1)=[O:40])(C(C)(C)C)(C)C.C(O)(=O)C>C1COCC1>[OH:26][C@H:27]([C:73]1[CH:82]=[CH:81][C:80]([OH:83])=[C:79]2[C:74]=1[CH:75]=[CH:76][C:77](=[O:84])[NH:78]2)[CH2:28][NH:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][NH:38][C:39]([C:41]1[CH:42]=[C:43]([S:47]([C:50]2[CH:51]=[C:52]3[C:57](=[C:58]([CH3:60])[CH:59]=2)[N:56]=[CH:55][C:54]([C:61]([NH2:63])=[O:62])=[C:53]3[NH:64][C:65]2[CH:70]=[CH:69][CH:68]=[C:67]([O:71][CH3:72])[CH:66]=2)(=[O:48])=[O:49])[CH:44]=[CH:45][CH:46]=1)=[O:40]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 2724141Tetrabutylammonium FluorideHCID 86659116(R)-6-[[3-[[8-[[2-[(tert-Butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl]ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

생성물 1

HCID 54588137(R)-6-[[3-[[8-[[2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide
수율 28.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of TBAF (1.0 M in THF, 0.244 mL, 0.244 mmol) was added to a stirring solution of Intermediate 148 (76 mg, 0.0813 mmol) in THF (2 mL) at rt. After stirring over night, glacial acetic acid (0.023 mL, 0.407 mmol) was added and stirred for an additional 16 h. The reaction mixture was concentrated and purified by PREP-HPLC to give the title compound (19 mg).

후처리

  1. stirringstirred for an additional 16 h
  2. concentrationThe reaction mixture was concentrated
  3. custompurified by PREP-HPLC

출처 및 근거

ORD 기록
ord-7529d12907a94d68b063a7911ae51904
출처 데이터셋
uspto-grants-2013_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08394829B2

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