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Potassium Carbonate → HCID 11428225, 화합물

HRID 1945198
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인쇄 미리보기

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HRID 1945198 반응식
[C:1](=[O:4])([O-])[O-:2].[K+].[K+].[Cl:7][C:8]1[CH:9]=[CH:10][C:11]2[O:16][CH2:15][C:14](=O)[NH:13][C:12]=2[CH:18]=1.[CH3:19][S:20]([C:23]1[CH:28]=[CH:27]C(F)=[CH:25][CH:24]=1)(=[O:22])=[O:21]>CN1C(=O)CCC1.O>[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([O:16][CH2:15][C:1]([OH:2])=[O:4])=[C:12]([NH:13][C:14]2[CH:27]=[CH:28][C:23]([S:20]([CH3:19])(=[O:22])=[O:21])=[CH:24][CH:25]=2)[CH:18]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 679941-Fluoro-4-(methylsulphonyl)benzeneHCID 3092596-Chloro-2H-1,4-benzoxazin-3(4H)-one

생성물 1

HCID 11428225HCID 11428225, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 13387N-methyl-2-pyrrolidone용매

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온도
120 °C

실험 절차

Potassium carbonate (0.265 g) was added to a solution of the product from step (ii) (0.44 g) and 4-fluorophenyl methyl sulfone (0.331 g) in NMP (20 ml) and the mixture heated at 120° C. for 16 h. The reaction was diluted with water and extracted with ethylacetate, the organics were dried and evaporated under reduced pressure. The residue was purified by reverse phase HPLC, yield 0.096 g.

후처리

  1. extractionextracted with ethylacetate
  2. customthe organics were dried
  3. customevaporated under reduced pressure
  4. customThe residue was purified by reverse phase HPLC, yield 0.096 g

출처 및 근거

ORD 기록
ord-96a716d733bf4eaebe5807d6ce9c08cf
출처 데이터셋
uspto-grants-2013_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08394986B2

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