Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trichlorophenoxyacetic acid → 3-[2-(2,4,5-Trichloro-phenoxy)-acetylamino]-benzoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trichlorophenoxyacetic acid | HCID 1480 | — |
| 반응물 | Benzoic acid, 3-amino-, methyl ester | HCID 78274 | — |
| 반응물 | PyBOP | HCID 2724699 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-[2-(2,4,5-Trichloro-phenoxy)-acetylamino]-benzoic acid methyl ester | HCID 24811001 | 85.6% |
반응 단계
The mixture of (2,4,5-trichloro-phenoxyacetic acid (127.8 mg, 0.5 mmol), 3-aminobenzoic acid methyl ester (151.2 mg, 1.0 mmol), 4-dimethylaminopyridine (122.2 mg, 1.0 mmol) and benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate (pybop) (520.3 g, 1.0 mmol) in DMF (5.0 mL) was stirred overnight and then partitioned between ethyl acetate and 10% HCl. The organic phase was washed with brine, dried (MgSO4 anh), and concentrated. The residue was purified by silica gel flash column chromatography (n-Hexane:Ethyl acetate:MeOH=6:3:1) to give 3-[2-(2,4,5-trichloro-phenoxy)-acetylamino]-benzoic acid methyl ester as a white solid (166.4 mg, 85.6% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08394799B2 |
| 출처 데이터셋 | uspto-grants-2013_03 |
| ORD ID | ord-abdd9bc9d0c347d5a931bf1da08883e2 |
| 출처 메모 | uspto-grants-2013_03 |