Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 2-[2-(4-Tert-butyl-phenoxy)-acetylamino]-isonicotinic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 2-(4-Tert-butylphenoxy)acetic acid | HCID 15718 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Aminoisonicotinamide | HCID 351653 | — |
| 반응물 | PyBOP | HCID 2724699 | — |
| 생성물 | 2-[2-(4-Tert-butyl-phenoxy)-acetylamino]-isonicotinic acid methyl ester | HCID 24812097 | 50.3% |
반응 단계
A solution of (4-tert-butyl-phenoxy)acetic acid (200.1 mg, 0.96 mmol), 2-amino-isonicotinamide (109.5 mg, 0.72 mmol), DIPEA (0.17 ml, 0.96 mmol) and PyBOP (499.5 mg, 0.96 mmol) in DMF 6.0 mL was stirred, then partitioned between ethyl acetate and water. The organic phase was purified by preparative TLC(Hexane:EtoAC:MeOH=15:3:1) to give 2-[2-(4-tert-butyl-phenoxy)-acetylamino]-isonicotinic acid methyl ester as a white solid (124.0 mg, 50.3% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08394799B2 |
| 출처 데이터셋 | uspto-grants-2013_03 |
| ORD ID | ord-36b99e1d20c54840a42e6cbee3b2a6b5 |
| 출처 메모 | uspto-grants-2013_03 |