Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 2-[2-(2,4,5-Trichloro-phenoxy)-acetylamino]-isonicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Trichlorophenoxyacetic acid | HCID 1480 | — |
| 반응물 | 2-Aminoisonicotinamide | HCID 351653 | — |
| 반응물 | PyBOP | HCID 2724699 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-[2-(2,4,5-Trichloro-phenoxy)-acetylamino]-isonicotinamide | HCID 58001320 | 41.1% |
반응 단계
To solution of (2,4,5-trichloro-phenoxyacetic acid (100 mg, 0.39 mmol), 2-amino isonicotinamide (107 mg, 0.78 mmol) and DMAP (96.22 mg, 0.78 mmol) in DMF 12 ml was added PyBOP (409.7 mg, 0.78 mmol), and stirred room temperature. Reaction mixture was poured onto ice cold water, diluted by methanol/MC mixture (10%). The organic phase was separated, sequentially washed with aqueous sodium bicarbonate, brine and water, dried over anhydrous MgSO4, and concentrated. The residue was purified by PLC (EtoAC:Hexane:MeOH=3:6:1-2:4:1) to afford 2-[2-(2,4,5-trichloro-phenoxy)-acetylamino]-isonicotinamide as a colorless solid (0.06 g, 41% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08394799B2 |
| 출처 데이터셋 | uspto-grants-2013_03 |
| ORD ID | ord-474952af8a0f467a9705947702d17dea |
| 출처 메모 | uspto-grants-2013_03 |