Methanol, 1,1-diethoxy-, 1-acetate → 5-Bromo-(1,2,4)triazolo(4,3-a)pyridine
반응식
[Br:1][C:2]1[N:7]=[C:6]([NH:8][NH2:9])[CH:5]=[CH:4][CH:3]=1.[C:10](OC(OCC)OCC)(=O)C>CCCCC>[Br:1][C:2]1[N:7]2[CH:10]=[N:9][N:8]=[C:6]2[CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
A solution of (6-bromopyridin-2-yl)hydrazine (500 mg, 2.66 mmol) in diethoxymethyl acetate (2.5 mL) was stirred at room temperature for 18 hours. The reaction mixture was diluted with pentane and filtered. The precipitate was washed with pentane and dried at 50° C. under vacuum for 1 hour to give 5-bromo-[1,2,4]triazolo[4,3-a]pyridine as a beige solid (410 mg, 78%). 1H NMR (400 MHz, CHCl3-d): δ 8.98 (s, 1 H); 7.83 (dt, J=9.2, 0.9 Hz, 1 H); 7.22 (dd, J=9.2, 7.0 Hz, 1 H); 7.09 (dd, J=7.0, 0.9 Hz, 1 H).
후처리
- filtrationfiltered
- washThe precipitate was washed with pentane
- customdried at 50° C. under vacuum for 1 hour
출처 및 근거
- ORD 기록
- ord-f045edc9168a4d579f5e77feb4960888
- 출처 데이터셋
- uspto-grants-2013_03
- 특허 번호
- US08394796B2
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