참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Ethylamine | HCID 6341 | — |
| 반응물 | 4-Bromo-1-chloroisoquinoline | HCID 459766 | — |
| 생성물 | 4-bromo-N-ethylisoquinolin-1-amine | HCID 59605203 | 88% |
반응 단계
To a suspension of 4-bromo-1 chloroisoquinoline (0.831 g, 3.43 mmol) in MeOH (10.3 mL, 254 mmol) was added ethylamine (70% in water, 1.1 mL). The mixture was heated at 50° C. for 16 h. The mixture was concentrated. The residue was partitioned between water (20 mL) and DCM (20 mL). DCM layer was separated. The aqueous layer was extracted with DCM (10 mL). The combined DCM solutions were dried (Na2SO4). Filtration and concentration gave 4-bromo-N-ethylisoquinolin-1-amine (0.761 g, 88%). LCMS: M+H+=251.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08394796B2 |
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| 출처 데이터셋 | uspto-grants-2013_03 |
|---|
| ORD ID | ord-4ac34d4c131d4132895ea6819fd19128 |
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| 출처 메모 | uspto-grants-2013_03 |
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