Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methylbenzimidazole → 5-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)-2-oxa-5-azabicyclo[2.2.1]heptane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methylbenzimidazole | HCID 11984 | — |
| 반응물 | 2-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-5-oxa-2-aza-bicyclo[2.2.1]heptane | HCID 86648262 | — |
| 생성물 | 5-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)-2-oxa-5-azabicyclo[2.2.1]heptane | HCID 59605324 | — |
반응 단계
Following General Procedure I for Buchwald coupling, 2-methylbenzimidazole and 2-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-5-oxa-2-aza-bicyclo[2.2.1]heptane were reacted to give 384. LCMS m/z: 461.2 (MH+)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08394796B2 |
| 출처 데이터셋 | uspto-grants-2013_03 |
| ORD ID | ord-e3fb0f4774704c4582247b0d5ed40411 |
| 출처 메모 | uspto-grants-2013_03 |