N-[1-({2-Chloro-6-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide → HCID 59547909, 화합물

HRID 1946301노트

반응식

HRID 1946301 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8]CC2C=CC=CC=2)[C:3]=1[CH2:16][N:17]1[CH:21]=[CH:20][C:19]([NH:22][C:23](=[O:32])[C:24]2[C:29]([F:30])=[CH:28][CH:27]=[CH:26][C:25]=2[F:31])=[N:18]1>C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[CH2:16][N:17]1[CH:21]=[CH:20][C:19]([NH:22][C:23](=[O:32])[C:24]2[C:29]([F:30])=[CH:28][CH:27]=[CH:26][C:25]=2[F:31])=[N:18]1

참가 물질

4

반응물 1

HCID 59547897N-[1-({2-Chloro-6-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide

생성물 1

HCID 59547909HCID 59547909, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매2회HCID 8857Ethyl Acetate용매

실험 절차

A solution of N-[1-({2-chloro-6-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide (for a preparation see Intermediate 10)(0.148 g, 0.326 mmol) in ethyl acetate (20 ml) was hydrogenated using an H-cube (settings: 20° C., 1 bar, 1 ml/min flow rate) and 5% Pd/C CatCart 30 as the catalyst. The solution was hydrogenated again using an H-cube (settings: 20° C., 1 bar, 1 ml/min flow rate) and 10% Pd/C CatCart 30 as the catalyst. The solvent was removed in vacuo to give the title compound as a colourless gum (70 mg); LCMS: (System 1) MH+=364, tRET=3.14 min.

후처리

  1. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-2732772066ed40a29122958fa3ba6059
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399436B2

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