Hydrazine → 6-(Propan-2-yl)-4,5-dihydropyridazin-3(2H)-one
반응식
[CH3:1][CH:2]([CH3:10])[C:3](=O)[CH2:4][CH2:5][C:6](O)=[O:7].[NH2:11][NH2:12]>C(O)C>[CH:2]([C:3]1[CH2:4][CH2:5][C:6](=[O:7])[NH:11][N:12]=1)([CH3:10])[CH3:1]참가 물질
4
실험 절차
5-Methyl-4-oxohexanoic acid (3.60 g, 25.0 mmol) and anhydrous hydrazine (0.80 g, 26.0 mmol) were heated for 3 hours in ethanol (36.0 ml) under stirring. After the reaction solution was concentrated under reduced pressure, hexane was added to the residues to precipitate crystals, and the crystals were collected by filtration to give 4,5-dihydro-6-isopropyl-3(2H)-pyridazinone as crystals. The yield was 3.10 g.
후처리
- concentrationAfter the reaction solution was concentrated under reduced pressure, hexane
- additionwas added to the residues
- customto precipitate crystals
- filtrationthe crystals were collected by filtration
출처 및 근거
- ORD 기록
- ord-89ea518887624acea03f3b30dd12e99f
- 출처 데이터셋
- uspto-grants-2013_03
- 특허 번호
- US08399381B2
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