Ethylamine → HCID 23028136, 화합물
반응식
[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7](Cl)=[N:6][N:5]2[C:11]=1[S:12]([NH2:15])(=[O:14])=[O:13].[CH2:16]([NH2:18])[CH3:17]>C(#N)C>[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([NH:18][CH2:16][CH3:17])=[N:6][N:5]2[C:11]=1[S:12]([NH2:15])(=[O:14])=[O:13]참가 물질
4
실험 절차
2,6-Dichloroimidazo[1,2-b]pyridazin-3-ylsulfonamide (2.00 g, 7.50 mmol) and ethylamine (50%, 10.0 ml) were stirred in acetonitrile (100 ml) at 70° C. for 8 hours. The reaction mixture was concentrated to dryness, dissolved in ice-water (50.0 ml), and adjusted to pH 6 with conc. hydrochloric acid. The precipitated crystals were filtered and washed with water to give the title compound as pale yellow crystals. The yield was 1.10 g (53.3%).
후처리
- concentrationThe reaction mixture was concentrated to dryness
- dissolutiondissolved in ice-water (50.0 ml)
- filtrationThe precipitated crystals were filtered
- washwashed with water
출처 및 근거
- ORD 기록
- ord-f9d7484b3602446bb993a611cbe366d8
- 출처 데이터셋
- uspto-grants-2013_03
- 특허 번호
- US08399381B2
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