Water → N-diphenylmethylsarcosine

HRID 19465

반응식

HRID 19465 반응식
[NH:1]([CH2:3][C:4]([OH:6])=[O:5])[CH3:2].[OH-].[K+].Cl[CH:10]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.O>C(O)(C)C>[C:11]1([CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:1]([CH2:3][C:4]([OH:6])=[O:5])[CH3:2])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 1088SarcosineHCID 7035Chlorodiphenylmethane2회HCID 14797Potassium Hydroxide

생성물 1

HCID 14966962N-diphenylmethylsarcosine수율 18%

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
50 °C

실험 절차

In a 250 ml three-necked flask equipped with a magnetic stirrer, a thermometer, a dropping funnel and a condenser, a mixture of sarcosine (4.45 g; 50 mmol) and KOH (8.47 g; 151 mmol) in 70 ml of isopropanol is prepared by heating the mixture to 50° C. The medium remains cloudy after 30 minutes then chlorodiphenylmethane (10.7 ml; 60 mmol) is added over 30 minutes at 50° C. The mixture is heated for 5 hours at this temperature. The mixture is then left to cool down to ambient temperature. After the addition of 100 ml of water, the pH is adjusted to 10 and the chlorodiphenylmethane which has not reacted is recovered after extraction with CHCl3. The pH is adjusted to 5-6 with concentrated HCl and the mixture is extracted once again with chloroform in order to produce 2.23 g of product (Yield=18%) in the form of colourless gum.

후처리

  1. customIn a 250 ml three-necked flask equipped with a magnetic stirrer
  2. customis prepared
  3. temperatureThe mixture is heated for 5 hours at this temperature
  4. waitThe mixture is then left
  5. temperatureto cool down to ambient temperature
  6. customis recovered
  7. extractionafter extraction with CHCl3
  8. extractionthe mixture is extracted once again with chloroform in order

출처 및 근거

ORD 기록
ord-275f00cdf8654295becbc7c5269b4d1b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745413B2

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