Potassium Hydroxide → 2,3,4,5-Tetrahydro-1,4-benzoxazepin-5-one

HRID 1946632

반응식

HRID 1946632 반응식
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[CH2:3][CH2:2]1.[N-:12]=[N+]=[N-].[Na+].[OH-].[K+]>S(=O)(=O)(O)O>[O:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[C:4](=[O:11])[NH:12][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 33557Sodium AzideHCID 68110Chromanone

생성물 1

HCID 3406292,3,4,5-Tetrahydro-1,4-benzoxazepin-5-one

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매2회

실험 절차

The chroman-4-one (5.0 g, 33.8 mmol) was dissolved in sulfuric acid (10 mL) and the mixture was cooled at 0 oC. Sodium azide (2.88 g, 44.3 mmol) was added portionwise followed by some sulfuric acid (5 mL). The reaction mixture was stirred at room temperature over night. The mixture was then pour into ice-water and basified to pH=7 with potassium hydroxide pellets. This aqueous layer was extracted with ether (twice).

후처리

  1. temperaturethe mixture was cooled at 0 oC
  2. extractionThis aqueous layer was extracted with ether (twice)

출처 및 근거

ORD 기록
ord-88a9b647d76b4d0aa3e7a773eadd29f4
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399452B2

연결된 노트

불러오는 중…