Trimethyl orthobeznoate → HCID 34176367, 화합물

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[Cl:1][C:2]1[C:7]([NH:8][NH2:9])=[N:6][CH:5]=[CH:4][N:3]=1.CO[C:12](OC)(OC)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[Cl:1][C:2]1[C:7]2[N:6]([C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[N:9][N:8]=2)[CH:5]=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 69720Trimethyl orthobeznoate

HCID 3214302-Chloro-3-hydrazinopyrazine

생성물 1

HCID 34176367HCID 34176367, 화합물수율 105.8%

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온도: 120 °C

실험 절차

Title compound 471 (0.8 g, 5.53 mmol) and Trimethyl orthobenzoate (5 mL, 29.1 mmol) were combined and the reaction mixture was stirred at 120° C. for 3 h. The mixture was cooled to room temperature and the solid was filtered and washed with hexanes to afford title compound 472 (1.35 g, 100%) as a beige solid. MS (m/z): 231.1 (M+H)

후처리

temperatureThe mixture was cooled to room temperature
filtrationthe solid was filtered
washwashed with hexanes

출처 및 근거

ORD 기록: ord-29dce790f8894150b6a23c49acdd6b7a
출처 데이터셋: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08399452B2

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