Ethyl 4-(4-nitrophenylsulfonyl)butanoate → Ethyl 4-(4-aminophenylsulfonyl)butanoate

HRID 1946703노트

반응식

HRID 1946703 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([S:10]([CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])(=[O:12])=[O:11])=[CH:6][CH:5]=1

참가 물질

4

반응물 1

HCID 59446990Ethyl 4-(4-nitrophenylsulfonyl)butanoate2회

생성물 1

HCID 59446984Ethyl 4-(4-aminophenylsulfonyl)butanoate수율 98.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of ethyl 4-(4-nitrophenylsulfonyl)butanoate (Intermediate 47, 4.5 g; 14.9 mmol) in ethanol (200 ml) was treated with palladium (450 mg, 5% on C). The mixture was stirred under hydrogen for 18 hours, filtered and the solvent removed in vacuo to give the title compound as an off-white solid (4.0 g, quant).

후처리

  1. filtrationfiltered
  2. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-bb81b7beb8f449bf8643989d6a333557
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399448B2

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