N,4-Dimethylcyclohexanamine → N-(4-hydroxy-2-methylphenyl)-6-[methyl(4-methylcyclohexyl)amino]pyrimidine-4-carboxamide

HRID 1946734

반응식

HRID 1946734 반응식
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][C:12]=2[CH3:18])=[O:9])[CH:3]=1.[CH3:19][NH:20][CH:21]1[CH2:26][CH2:25][CH:24]([CH3:27])[CH2:23][CH2:22]1>>[OH:17][C:14]1[CH:15]=[CH:16][C:11]([NH:10][C:8]([C:4]2[CH:3]=[C:2]([N:20]([CH3:19])[CH:21]3[CH2:26][CH2:25][CH:24]([CH3:27])[CH2:23][CH2:22]3)[N:7]=[CH:6][N:5]=2)=[O:9])=[C:12]([CH3:18])[CH:13]=1

참가 물질

3

반응물 2

HCID 4962029N,4-DimethylcyclohexanamineHCID 594471056-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide2회

생성물 1

HCID 25182771N-(4-hydroxy-2-methylphenyl)-6-[methyl(4-methylcyclohexyl)amino]pyrimidine-4-carboxamide

실험 절차

Following the general method as outlined in Example 20, starting from 6-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide (Intermediate 8) and N,4-dimethylcyclohexanamine (Enamine), the title compound was obtained as a mixture of cis-trans stereoisomers, as a yellow solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.

출처 및 근거

ORD 기록
ord-bb1a575b101f4891b0807757b3fbb061
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399448B2

연결된 노트

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