홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

1,4-Dioxane hydrochloride → 5-(2,4-Dihydroxy-5-isopropylphenyl)-4-[4-(4-methylpiperazin-1-ylmethyl)phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

HRID 1947212
노트
인쇄 미리보기

반응식

HRID 1947212 반응식
Cl.O1CCOCC1.[CH:8]([C:11]1[C:12]([O:41]COC)=[CH:13][C:14]([O:37]COC)=[C:15]([C:17]2[N:18]([C:23]3[CH:28]=[CH:27][C:26]([CH2:29][N:30]4[CH2:35][CH2:34][N:33]([CH3:36])[CH2:32][CH2:31]4)=[CH:25][CH:24]=3)[C:19](=[O:22])[NH:20][N:21]=2)[CH:16]=1)([CH3:10])[CH3:9]>CO>[OH:37][C:14]1[CH:13]=[C:12]([OH:41])[C:11]([CH:8]([CH3:10])[CH3:9])=[CH:16][C:15]=1[C:17]1[N:18]([C:23]2[CH:24]=[CH:25][C:26]([CH2:29][N:30]3[CH2:31][CH2:32][N:33]([CH3:36])[CH2:34][CH2:35]3)=[CH:27][CH:28]=2)[C:19](=[O:22])[NH:20][N:21]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 204431481,4-Dioxane hydrochlorideHCID 598298715-(5-Isopropyl-2,4-bis-methoxymethoxyphenyl)-4-[4-(4-methylpiperazin-1-ylmethyl)phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

생성물 1

HCID 1359070425-(2,4-Dihydroxy-5-isopropylphenyl)-4-[4-(4-methylpiperazin-1-ylmethyl)phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
40 °C

실험 절차

At room temperature, 4 N hydrochloric acid/1,4-dioxane solution (5 mL) was added to a methanol (5 mL) solution of 5-(5-isopropyl-2,4-bis-methoxymethoxyphenyl)-4-[4-(4-methyl piperazin-1-ylmethyl)phenyl]-2,4-dihydro-[1,2,4]triazol-3-one (F652-09, 644 mg, 1.26 mmol). After stirring at 40° C. for 1 hour, the solvent was distilled off under reduced pressure. Methanol was added to the crude product thus obtained, and the resulting suspension was stirred at room temperature. The precipitated solid was collected by filtration to obtain 5-(2,4-dihydroxy-5-isopropylphenyl)-4-[4-(4-methylpiperazin-1-ylmethyl)phenyl]-2,4-dihydro-[1,2,4]triazol-3-one (OH-a13) dihydrochloride (white solids).

후처리

  1. distillationthe solvent was distilled off under reduced pressure
  2. additionMethanol was added to the crude product
  3. customthus obtained
  4. stirringthe resulting suspension was stirred at room temperature
  5. filtrationThe precipitated solid was collected by filtration

출처 및 근거

ORD 기록
ord-f8309d77c0494fc7b46e66720e4179dc
출처 데이터셋
uspto-grants-2013_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08399464B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트