Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1947389생성일: 2026년 10월 27일
4,4'-Dibromobiphenyl → Ethyl (3ar,6ar)-1-(4'-bromo-1,1'-biphenyl-4-yl)hexahydropyrrolo[3,4-b]pyrrole-5(1h)-carboxylate
https://huagongshe.com/reaction/1947389
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4,4'-Dibromobiphenyl | HCID 7110 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | (3AR,6AR)-5-Ethoxycarbonyl-1H-hexahydropyrrolo[3,4-B]pyrrole | HCID 24743918 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Ethyl (3ar,6ar)-1-(4'-bromo-1,1'-biphenyl-4-yl)hexahydropyrrolo[3,4-b]pyrrole-5(1h)-carboxylate | HCID 67397057 | — |
반응 단계
The catalyst solution was added to the vessel containing the 4,4′-dibromobiphenyl, cesium carbonate, and the product of Example 41C and the mixture was heated to 98° C. for 12 hours. The mixture was cooled to 20° C. and 80 g of dichloromethane was added. The resulting mixture was stirred and then filtered to remove the catalyst. The resulting solution was concentrated under reduced pressure and the residue was purified by column chromatography to yield 5.65 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08399468B2 |
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| 출처 데이터셋 | uspto-grants-2013_03 |
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| ORD ID | ord-5e9959faad2b4997bcd71b1aa74fc6e8 |
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| 출처 메모 | uspto-grants-2013_03 |
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