2-cyclohexyl-1-ethyl-5-nitro-1H-indole → 2-cyclohexyl-1-ethyl-1H-indol-5-amine

HRID 1947434노트

반응식

HRID 1947434 반응식
[CH:1]1([C:7]2[N:8]([CH2:19][CH3:20])[C:9]3[C:14]([CH:15]=2)=[CH:13][C:12]([N+:16]([O-])=O)=[CH:11][CH:10]=3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>[Pd].C(O)C>[CH:1]1([C:7]2[N:8]([CH2:19][CH3:20])[C:9]3[C:14]([CH:15]=2)=[CH:13][C:12]([NH2:16])=[CH:11][CH:10]=3)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

4

반응물 1

HCID 672850022-cyclohexyl-1-ethyl-5-nitro-1H-indole

생성물 1

HCID 672845702-cyclohexyl-1-ethyl-1H-indol-5-amine수율 91.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매2회

실험 절차

To a suspension of 10% Pd/C (380 mg, 0.36 mmol) in 95° ethanol (50 ml) a solution of 2-cyclohexyl-1-ethyl-5-nitro-1H-indole (4.8 g; 18 mmol) in 95° ethanol (100 ml) was added and the mixture underwent hydrogenation in a Parr hydrogenator (H2, 30 psi) for 4 hours. The residue was filtered under vacuum through Celite to remove the catalyst and the solvent evaporated to give crude 2-cyclohexyl-1-ethyl-1H-indol-5-amine (4 g) which was used without any further purification.

후처리

  1. additionwas added
  2. filtrationThe residue was filtered under vacuum through Celite
  3. customto remove the catalyst
  4. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-42065b700b2040ae9ead90ef3ec11dd2
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399477B2

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