Trifluoroacetic acid → 7-amino-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

HRID 1947889노트

반응식

HRID 1947889 반응식
C(OC([NH:8][C:9]1[C:17]2[C:16](=[O:18])[N:15]([CH3:19])[CH2:14][C:13]=2[C:12]([C:20]([OH:22])=[O:21])=[CH:11][CH:10]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>>[NH2:8][C:9]1[C:17]2[C:16](=[O:18])[N:15]([CH3:19])[CH2:14][C:13]=2[C:12]([C:20]([OH:22])=[O:21])=[CH:11][CH:10]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 672564057-[(Tert-butoxycarbonyl)amino]-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

생성물 1

HCID 672542797-amino-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

실험 절차

The title compound was prepared by deprotecting Compound 116C with TFA. The crude product was taken on to the next step without purification.

후처리

  1. customThe crude product was taken on to the next step without purification

출처 및 근거

ORD 기록
ord-b0aba7bb9d2343b3939ab5a3f0f58a1b
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399433B2

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