2-Amino-5-fluoro-N-methylbenzamide → Diethyl (4-amino-3-fluoro-5-methoxybenzyl)phosphonate
반응식
NC1C=CC(F)=CC=1C(NC)=O.[F:13][C:14]1[CH:15]=[C:16]([CH:26]=[C:27]([O:32][CH3:33])[C:28]=1[N+:29]([O-])=O)[CH2:17][P:18](=[O:25])([O:22][CH2:23][CH3:24])[O:19][CH2:20][CH3:21]>>[NH2:29][C:28]1[C:27]([O:32][CH3:33])=[CH:26][C:16]([CH2:17][P:18](=[O:25])([O:22][CH2:23][CH3:24])[O:19][CH2:20][CH3:21])=[CH:15][C:14]=1[F:13]참가 물질
3
실험 절차
The title compound was prepared using the procedure from Compound 102A (2-Amino-5-fluoro-N-methylbenzamide) with Diethyl (3-fluoro-5-methoxy-4-nitrobenzyl)phosphonate (Compound 146B). 1H NMR (CDCl3, 400 MHz): δ=1.27 (t, J=7.07 Hz, 6H), 2.99-3.08 (m, 2H), 3.87 (s, 3H), 4.00-4.06 (m, 4H), 6.59 (s, 1H), 6.63 (dt, J=10.74, 2.21 Hz, 1H). MS (ES+): m/z 292.06 [MH+] (TOF, polar).
출처 및 근거
- ORD 기록
- ord-cbd200dc5be84042aef7b6a1f4681a45
- 출처 데이터셋
- uspto-grants-2013_03