8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro(4.5)dec-7-ene → 4-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one

HRID 1947997노트

반응식

HRID 1947997 반응식
[O:1]1[C:5]2([CH2:10][CH2:9][C:8](C3C4C(=CC=CC=4)C(=O)N3C)=[CH:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.Br[C:23]1[CH:31]=[CH:30][C:29]([N+:32]([O-:34])=[O:33])=[C:28]2[C:24]=1[CH2:25][N:26]([CH3:36])[C:27]2=[O:35].O1C2(CCC(B3OC(C)(C)C(C)(C)O3)=CC2)OCC1>>[O:1]1[C:5]2([CH2:10][CH2:9][C:8]([C:23]3[CH:31]=[CH:30][C:29]([N+:32]([O-:34])=[O:33])=[C:28]4[C:24]=3[CH2:25][N:26]([CH3:36])[C:27]4=[O:35])=[CH:7][CH2:6]2)[O:4][CH2:3][CH2:2]1

참가 물질

4

반응물 3

HCID 36970768-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro(4.5)dec-7-eneHCID 534078944-Bromo-2-methyl-7-nitroisoindolin-1-oneHCID 866540391,4-dioxaspiro[4,5]dec-7-ene-8-yl-2-methyl-2,3-dihydro-1H-isoindol-1-one

생성물 1

HCID 672551534-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one

실험 절차

The title product was prepared according to the procedure for 7-amino-4-(1,4-dioxaspiro[4,5]dec-7-ene-8-yl-2-methyl-2,3-dihydro-1H-isoindol-1-one using 4-bromo-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one and 1,4-dioxaspiro[4,5]dec-7-ene-8-boronic acid pinacol ester.

출처 및 근거

ORD 기록
ord-de27d78890cb484da103de2be11cc817
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399433B2

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