Trifluoroacetic acid → 7-amino-4-(3,4-dihydroxycyclopentyl)-2-methyl-2,3-dihydro-1H-isoindol-1-one trifluoroacetate

HRID 1948058노트

반응식

HRID 1948058 반응식
C(OC(=O)[NH:7][C:8]1[CH:16]=[CH:15][C:14]([CH:17]2[CH2:21][CH:20]([OH:22])[CH:19]([OH:23])[CH2:18]2)=[C:13]2[C:9]=1[C:10](=[O:25])[N:11]([CH3:24])[CH2:12]2)(C)(C)C.[C:27]([OH:33])([C:29]([F:32])([F:31])[F:30])=[O:28]>C(Cl)Cl>[F:30][C:29]([F:32])([F:31])[C:27]([OH:33])=[O:28].[NH2:7][C:8]1[CH:16]=[CH:15][C:14]([CH:17]2[CH2:18][CH:19]([OH:23])[CH:20]([OH:22])[CH2:21]2)=[C:13]2[C:9]=1[C:10](=[O:25])[N:11]([CH3:24])[CH2:12]2

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86695307tert-butyl[7-(3,4-dihydroxycyclopentyl)-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl]carbamate2회

생성물 1

HCID 672550847-amino-4-(3,4-dihydroxycyclopentyl)-2-methyl-2,3-dihydro-1H-isoindol-1-one trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of tert-butyl[7-(3,4-dihydroxycyclopentyl)-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl]carbamate (Compound 243B, 36 mg, 0.099 mmol) in DCM (2 mL) was added TFA (1 mL). The resulting mixture was stirred at rt for 30 min, then evaporated under reduced pressure to give the desired product. This TFA salt was directly used in next step. MS (ES+): m/z=263.09 [MH+]. HPLC: tR=0.78 min (ZQ3, polar—5 min).

후처리

  1. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-5b0a2c0bbd434238b99137d96c56988d
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399433B2

반응 노트

불러오는 중…