Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Fluorobenzyl bromide → 5-Bromo-1-(3-fluorobenzyl)pyridin-2(1H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Fluorobenzyl bromide | HCID 68007 | — |
| 반응물 | 5-Bromo-2-hydroxypyridine | HCID 599528 | — |
| 생성물 | 5-Bromo-1-(3-fluorobenzyl)pyridin-2(1H)-one | HCID 60627653 | 62% |
반응 단계
According to Scheme 1 Step 2: 1-(3-Fluorobenzyl)-5-bromopyridin-2(1H)-one was prepared from 5-bromopyridin-2(1H)-one (Example 1 Step 1) and 3-fluorobenzyl bromide according to the procedure described for Example 2 Step 1. The crude product washed with pentane/Et2O 50/50 to afford 1-(3-fluorobenzyl)-5-bromopyridin-2(1H)-one (10.7 mmol, 3.00 g, 62%) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08399493B2 |
| 출처 데이터셋 | uspto-grants-2013_03 |
| ORD ID | ord-0392181931214d6895b9cc6ab62bf4a2 |
| 출처 메모 | uspto-grants-2013_03 |