1-(Bromomethyl)-4-chlorobenzene → HCID 69350494, 화합물

HRID 1948250노트

반응식

HRID 1948250 반응식
[Br:1][C:2]1[N:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.Br[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1>C(#N)C>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][N:6]2[CH:7]=[C:2]([Br:1])[N:3]=[CH:4][C:5]2=[O:8])=[CH:12][CH:13]=1

참가 물질

4

반응물 2

HCID 693291-(Bromomethyl)-4-chlorobenzeneHCID 27716182-Bromo-5-hydroxypyrazine

생성물 1

HCID 69350494HCID 69350494, 화합물수율 87%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

According to Scheme 27 Step 1: The title compound was prepared from 5-bromopyrazin-2(1H)-one (1 eq, 2.86 mmol, 0.50 g) and 1-(bromomethyl)-4-chlorobenzene (1.5 eq, 4.29 mmol, 0.88 g) according to the procedure described for Example 1 Step 2. Reaction conditions: 3 hours at 70° C. in acetonitrile. The crude product was purified by flash chromatography over silica gel (AIT Flashsmart prepacked column 25 g SiO2) using pure AcOEt as eluent to afford 1-(4-chlorobenzyl)-5-bromopyrazin-2(1H)-one (2.48 mmol, 0.74 g, 87%) as a white solid.

후처리

  1. customReaction conditions
  2. custom3 hours
  3. customat 70° C.
  4. customThe crude product was purified by flash chromatography over silica gel (AIT Flashsmart prepacked column 25 g SiO2)

출처 및 근거

ORD 기록
ord-324b206e1ccd48708be64594c9618657
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399493B2

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