HCID 86229373, 화합물 → 1-((6-ethylpyridin-3-yl)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one

HRID 1948281노트

반응식

HRID 1948281 반응식
[C:1]([C:3]1[N:8]=[CH:7][C:6]([CH2:9][N:10]2[CH:15]=[C:14]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=3)[CH:13]=[CH:12][C:11]2=[O:24])=[CH:5][CH:4]=1)#[CH:2]>CO.[Pd]>[CH2:1]([C:3]1[N:8]=[CH:7][C:6]([CH2:9][N:10]2[CH:15]=[C:14]([C:16]3[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=3)[CH:13]=[CH:12][C:11]2=[O:24])=[CH:5][CH:4]=1)[CH3:2]

참가 물질

4

반응물 1

HCID 86229373HCID 86229373, 화합물

생성물 1

HCID 589669071-((6-ethylpyridin-3-yl)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one수율 62.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

According to Scheme 33 Step 3: To a suspension of Pd/C 10% (0.05 eq) in MeOH (10 mL) under N2 atmosphere, a solution of 1-((6-ethynylpyridin-3-yl)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one (0.15 mmol, 48 mg) was added at room temperature. The flask was evacuated and filled with hydrogen until the pressure reached 20 psi. The resulting suspension was shaken at room temperature for 1 hour. The catalyst was filtered off and the filtrate was evaporated under vacuum to give a residue. The residue was purified in a circular chromatography-TLC CH2Cl2/MeOH(NH3)sat. 2% yielding 1-((6-ethylpyridin-3-yl)methyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one (30 mg, 61%).

후처리

  1. customThe flask was evacuated
  2. additionfilled with hydrogen until the pressure
  3. filtrationThe catalyst was filtered off
  4. customthe filtrate was evaporated under vacuum
  5. customto give a residue
  6. customThe residue was purified in a circular chromatography-TLC CH2Cl2/MeOH(NH3)sat

출처 및 근거

ORD 기록
ord-9dc32c85029c47c7a30744927bdcf862
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399493B2

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