tert-butyl 4-chloro-3-fluoro-5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole-2-carboxylate → 4-chloro-3-fluoro-5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole-2-carboxylic acid

HRID 1948377노트

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HRID 1948377 반응식
[Cl:1][C:2]1[C:3]([F:23])=[C:4]([C:16]([O:18]C(C)(C)C)=[O:17])[N:5]([CH2:8][O:9][CH2:10][CH2:11][Si:12]([CH3:15])([CH3:14])[CH3:13])[C:6]=1[CH3:7]>CN1CCCC1=O>[Cl:1][C:2]1[C:3]([F:23])=[C:4]([C:16]([OH:18])=[O:17])[N:5]([CH2:8][O:9][CH2:10][CH2:11][Si:12]([CH3:14])([CH3:15])[CH3:13])[C:6]=1[CH3:7]

참가 물질

3

반응물 1

HCID 68516579tert-butyl 4-chloro-3-fluoro-5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole-2-carboxylate2회

생성물 1

HCID 685160854-chloro-3-fluoro-5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole-2-carboxylic acid

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

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온도
200 °C

실험 절차

tert-butyl 4-chloro-3-fluoro-5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole-2-carboxylate (Intermediate 264, 100 mg) was dissolved in N-methylpyrrolidinone (10 ml), heated to 200° C. for 30 minutes. The resulting solution was carried on to the next step without further purification.

후처리

  1. customThe resulting solution was carried on to the next step without further purification

출처 및 근거

ORD 기록
ord-447cf5db8bda49e8be118a8d969ff446
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399489B2

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