Triethylamine → 2-(2-Phenylpropyl)imidazolidin-4-one
반응식
[C:1]1([CH:7]([CH3:11])[CH2:8][CH:9]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:13][CH2:14][C:15]([NH2:17])=[O:16].C(N(CC)CC)C.C([O-])([O-])=O.[K+].[K+]>C(O)C>[C:1]1([CH:7]([CH3:11])[CH2:8][CH:9]2[NH:17][C:15](=[O:16])[CH2:14][NH:13]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1참가 물질
6
반응 조건
- 온도
- 60 °C
실험 절차
A mixture of 3-phenylbutanal (Trifernal®, 0.67 g, 4.5 mmol), glycinamide hydrochloride (0.50 g, 4.5 mmol), triethylamine (0.46 g, 4.5 mmol) and K2CO3 in ethanol (4 ml) was heated to 60° C. for 24 h. Then the solvent was removed under vacuum at 40° C. The residue was taken up in ether and the solvent evaporated to yield 0.52 g (57%) of a highly viscous oil as a mixture of diastereoisomers.
후처리
- customThen the solvent was removed under vacuum at 40° C
- customthe solvent evaporated
- customto yield 0.52 g (57%) of a highly viscous oil
- additionas a mixture of diastereoisomers
출처 및 근거
- ORD 기록
- ord-625699e9e27741c5be5c208f1d623f40
- 출처 데이터셋
- uspto-grants-2013_03
- 특허 번호
- US08399499B2
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