참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Ethenylbenzonitrile | HCID 76967 | — |
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-Hydroxy-4-vinyl-benzamidine | HCID 74440816 | 96.7% |
반응 단계
To a mixture of 4-vinylbenzonitrile (4.36 g, 33.8 mmol) and hydroxylamine hydrochloride (4.69 g, 67.5 mmol) in 2-propanol (50 mL) was added sodium bicarbonate (11.34 g, 135 mmol). The reaction mixture was heated at 80° C. for 2 hours. The reaction mixture was diluted with ethyl acetate and washed with water. The organic layer was dried MgSO4, filtered, and concentrated to yield 5.3 g of N′-hydroxy-4-vinylbenzimidamide. MS (m+1)=163. HPLC Peak RT=0.53 minutes (Analytical Method B).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08399451B2 |
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| 출처 데이터셋 | uspto-grants-2013_03 |
|---|
| ORD ID | ord-9cd4ae3661cf457e8a0ec17500c06b94 |
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| 출처 메모 | uspto-grants-2013_03 |
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