Sodium Carbonate → 2-(Triethylsilyl)-1H-pyrrolo[2,3-b]pyridine-3-ethanol

HRID 1948622노트

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HRID 1948622 반응식
I[C:2]1[C:3]([NH2:8])=[N:4][CH:5]=[CH:6][CH:7]=1.[CH2:9]([Si:11]([CH2:19][CH3:20])([CH2:17][CH3:18])[C:12]#[C:13][CH2:14][CH2:15][OH:16])[CH3:10].[Cl-].[Li+].C(=O)([O-])[O-].[Na+].[Na+]>CN(C=O)C.ClCCl.[Pd](Cl)Cl.C1(P(C2C=CC=CC=2)[C-]2C=CC=C2)C=CC=CC=1.[C-]1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=C1.[Fe+2].O.CCOC(C)=O.CCOCC>[CH2:19]([Si:11]([CH2:9][CH3:10])([CH2:17][CH3:18])[C:12]1[NH:8][C:3]2=[N:4][CH:5]=[CH:6][CH:7]=[C:2]2[C:13]=1[CH2:14][CH2:15][OH:16])[CH3:20]

참가 물질

9

반응물 4

HCID 10340Sodium CarbonateHCID 433294Lithium ChlorideHCID 27606944-(Triethylsilyl)-3-butyn-1-olHCID 27631512-Amino-3-iodopyridine

생성물 1

HCID 153510022-(Triethylsilyl)-1H-pyrrolo[2,3-b]pyridine-3-ethanol수율 80%

시약·촉매·용매 4

HCID 178418807HCID 178418807, 화합물촉매HCID 962Water용매HCID 6228Dimethylformamide용매HCID 21584169Diethylether ethylacetate용매

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온도
100 °C

실험 절차

A mixture of 3-iodopyridin-2-amine (0.46 g, 2.09 mmole), 4-(triethylsilyl)but-3-in-1-ol (0.58 g, 3.14 mmole), 1,1′-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane (0.083 g, 0.105 mmole), lithium chloride (0.086 g, 2.09 mmole) and sodium carbonate (0.44 g, 4.18 mmole) in DMF (21 ml) was stirred under nitrogen for 15 hours at 100° C. The reaction mixture was cooled to RT, EtOAc/ether (1:1) was added and the mixture was poured into H2O. The two-phase suspension was filtered through filter earth. After separating the phases the aqueous phase was extracted with EtOAc (2×). The organic phases were combined and washed with H2O and with saturated NaCl solution and dried over MgSO4. After filtering off the drying agent the solvents were removed on a rotary evaporator. Column chromatography of the residue (n-hexane/EtOAc=2:1, then n-hexane/EtOAc=1:1) yielded 2-(2-(triethylsilyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanol (0.46 g, 80%).

후처리

  1. temperatureThe reaction mixture was cooled to RT
  2. filtrationThe two-phase suspension was filtered
  3. filtrationthrough filter earth
  4. customAfter separating the phases the aqueous phase
  5. extractionwas extracted with EtOAc (2×)
  6. washwashed with H2O and with saturated NaCl solution
  7. dry with materialdried over MgSO4
  8. filtrationAfter filtering off the drying agent the solvents
  9. customwere removed on a rotary evaporator

출처 및 근거

ORD 기록
ord-43627da9ba3f47e29089f3068481d981
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399503B2

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