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Sodium Carbonate → (E)-3-[1-(4-Pyridin-3-ylphenylsulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester

HRID 1948646
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HRID 1948646 반응식
BrC1C=CC(S([N:11]2[CH:15]=[CH:14][C:13](/[CH:16]=[CH:17]/C(O)=O)=C2)(=O)=O)=CC=1.[C:21]([O:25][C:26](=[O:44])/[CH:27]=[CH:28]/[C:29]1[CH:33]=[CH:32][N:31]([S:34]([C:37]2[CH:42]=[CH:41][C:40](Br)=[CH:39][CH:38]=2)(=[O:36])=[O:35])[CH:30]=1)([CH3:24])([CH3:23])[CH3:22].N1C=CC=C(B(O)O)C=1.C(=O)([O-])[O-].[Na+].[Na+]>COCCOC.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Pd](Cl)Cl>[C:21]([O:25][C:26](=[O:44])/[CH:27]=[CH:28]/[C:29]1[CH:33]=[CH:32][N:31]([S:34]([C:37]2[CH:42]=[CH:41][C:40]([C:16]3[CH:17]=[N:11][CH:15]=[CH:14][CH:13]=3)=[CH:39][CH:38]=2)(=[O:36])=[O:35])[CH:30]=1)([CH3:24])([CH3:23])[CH3:22]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 10340Sodium CarbonateHCID 27343783-Pyridinylboronic acidHCID 66646304(E)-3-[1-(4-bromo-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester2회HCID 68524810(E)-3-[1-(4-Bromo-benzenesulfonyl)-1H-pyrrol-3-yl]acrylic acid

생성물 1

HCID 66646399(E)-3-[1-(4-Pyridin-3-ylphenylsulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester

시약·촉매·용매 2

HCID 13169693Triphenylphosphine palladium dichloride촉매HCID 80711,2-Dimethoxyethane용매

실험 절차

0.18 g (E)-3-[1-(4-bromo-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylic acid tart-butyl ester (compound D4) and 62 mg 3-pyridylboronic acid are dissolved in 10 ml DME. A catalytic amount of bis-(triphenylphosphin-palladium (II)-chloride and 0.6 ml of an aqueous solution of sodium carbonate are added and the mixture is heated to reflux temperature overnight. The title compound is isolated by means of chromatography.

후처리

  1. temperaturethe mixture is heated
  2. temperatureto reflux temperature overnight

출처 및 근거

ORD 기록
ord-8b96fb1f3d1e488cbe5a15f446aac6f1
출처 데이터셋
uspto-grants-2013_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08399505B2

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