Isopropyl chloroformate → (R)-3-Isopropoxycarbonylamino-pyrrolidine-1-carboxylic acid adamantan-2-yl ester

HRID 1948700

반응식

HRID 1948700 반응식
Cl.[NH2:2][C@@H:3]1[CH2:7][CH2:6][N:5]([C:8]([O:10][CH:11]2[CH:18]3[CH2:19][CH:14]4[CH2:15][CH:16]([CH2:20][CH:12]2[CH2:13]4)[CH2:17]3)=[O:9])[CH2:4]1.Cl[C:22]([O:24][CH:25]([CH3:27])[CH3:26])=[O:23]>>[CH:25]([O:24][C:22]([NH:2][C@@H:3]1[CH2:7][CH2:6][N:5]([C:8]([O:10][CH:11]2[CH:12]3[CH2:13][CH:14]4[CH2:15][CH:16]([CH2:17][CH:18]2[CH2:19]4)[CH2:20]3)=[O:9])[CH2:4]1)=[O:23])([CH3:27])[CH3:26]

참가 물질

3

반응물 2

HCID 7917Isopropyl chloroformateHCID 67155574(R)-2-adamantyl 3-aminopyrrolidine-1-carboxylate HCl salt

생성물 1

HCID 44473369(R)-3-Isopropoxycarbonylamino-pyrrolidine-1-carboxylic acid adamantan-2-yl ester

실험 절차

The title compound was prepared from (R)-2-adamantyl 3-aminopyrrolidine-1-carboxylate HCl salt and isopropyl chloroformate following a procedure analogous to that described in Example 3 Step 2. LC-MS Method 1 tR=1.98 min, m/z=351; 1H NMR (CDCl3) 1.24 (d, 6H), 1.57 (d, 2H), 1.70-2.00 (13H), 2.18 (m, 1H), 3.16 (1H), 3.49 (m, 2H), 3.69 (m, 1H), 4.24 (m, 1H), 4.74 (1H), 4.82 (s, 1H), 4.93 (m, 1H)

출처 및 근거

ORD 기록
ord-a2109844f347457f9f68d64b993a2db8
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399504B2

연결된 노트

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