2-Pyridinamine, 5-iodo- → 2-(4'-Hydroxy-3'-methoxyphenyl)-6-iodoimidazo[1,2-a]pyridine hydrobromide salt

HRID 1948868

반응식

HRID 1948868 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([O:12][CH3:13])[CH:6]=1)=O.[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([I:21])=[CH:17][N:16]=1>C(#N)C>[BrH:1].[OH:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:14]=[C:15]3[CH:20]=[CH:19][C:18]([I:21])=[CH:17][N:16]3[CH:2]=2)=[CH:6][C:7]=1[O:12][CH3:13]

참가 물질

4

반응물 2

HCID 885792-Pyridinamine, 5-iodo-HCID 135422582-Bromo-1-(4-hydroxy-3-methoxyphenyl)ethan-1-one

생성물 1

HCID 687195562-(4'-Hydroxy-3'-methoxyphenyl)-6-iodoimidazo[1,2-a]pyridine hydrobromide salt

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

First, 2-bromo-4′-hydroxy-3′-methoxyacetophenone and 2-amino-5-iodopyridine are dissolved in an inactive solvent such as acetonitrile, and are allowed to react with each other at a reflux temperature for 2 to 6 hours to produce 2-(4′-hydroxy-3′-methoxyphenyl)-6-iodoimidazo[1,2-a]pyridine hydrobromide salt as white precipitates. The solvent used in this instance may be acetonitrile or another solvent that is usually employed in a similar reaction, for example, methanol and acetone. The reaction temperature may be a temperature allowing refluxing, for example, 110° C. when the solvent is acetonitrile. The amount of the solvent to be used may be an amount sufficient to effect the reaction, however, it should be noted that if the solvent is too much, it will become difficult to obtain precipitates of reaction products. For example, when 2-bromo-4′-hydroxy-3′-methoxyacetophenone in an amount corresponding to 2 mmol is used for the reaction, the amount of a solvent to be used can be about 15 to 30 mL.

후처리

  1. customto react with each other at a reflux temperature for 2 to 6 hours

출처 및 근거

ORD 기록
ord-be4bb38fcbb84033ad4506e283d659ad
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399672B2

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