HCID 58277355, 화합물 → HCID 58277403, 화합물

HRID 1949214노트

반응식

HRID 1949214 반응식
C([O:8][C:9]1[CH:10]=[C:11]([C:15]2[N:19]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[CH:21]=3)[N:18]=[C:17]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[CH:16]=2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>C(O)(=O)C.[Pd]>[Cl:26][C:22]1[CH:21]=[C:20]([N:19]2[C:15]([C:11]3[CH:12]=[CH:13][CH:14]=[C:9]([OH:8])[CH:10]=3)=[CH:16][C:17]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[N:18]2)[CH:25]=[CH:24][CH:23]=1

참가 물질

4

반응물 1

HCID 58277355HCID 58277355, 화합물

생성물 1

HCID 58277403HCID 58277403, 화합물수율 84%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

19.1 g (44.1 mmol) of the compound of Example 43A are provided in 367 ml of conc. acetic acid, 23.5 g (11.0 mmol) of palladium on activated carbon (5%) are added, and the mixture is stirred under a hydrogen atmosphere at room temperature overnight. The reaction mixture is subsequently filtered, the filtrate is concentrated, the residue is taken up in dichloromethane and washed with an aqueous sodium bicarbonate solution, and the organic phase is dried over sodium sulfate and concentrated. 12.7 g of the title compound with 63% purity (53% of theory) are obtained.

후처리

  1. filtrationThe reaction mixture is subsequently filtered
  2. concentrationthe filtrate is concentrated
  3. washwashed with an aqueous sodium bicarbonate solution
  4. dry with materialthe organic phase is dried over sodium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1b507b665854474cbfbe96005653bd37
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399682B2

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