Acetonitrile--water (1/1) → HCID 58277330, 화합물

HRID 1949273노트

반응식

HRID 1949273 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH2:20][CH2:21][O:22][CH3:23])[CH:14]=3)=[CH:11][C:10]([C:24]([O:26]CC)=[O:25])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.ClC1C=C(N2C(C3C=C(F)C=C(Cl)C=3)=CC(C(O)=O)=N2)C=CC=1F.C(#N)C.O>C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH2:20][CH2:21][O:22][CH3:23])[CH:14]=3)=[CH:11][C:10]([C:24]([OH:26])=[O:25])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 18373917Acetonitrile--water (1/1)HCID 58277295HCID 58277295, 화합물HCID 58277326HCID 58277326, 화합물

생성물 1

HCID 58277330HCID 58277330, 화합물

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

The preparation of the title compound takes place starting from the compound of Example 69A in analogy to the synthesis of the compound of Example 71A and with purification by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with the addition of 0.1% formic acid). 46 mg (100% of theory) of the title compound are obtained.

출처 및 근거

ORD 기록
ord-e6165780e3334aa8816aba2d1793a346
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399682B2

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