HCID 58277330, 화합물 → HCID 58277274, 화합물

HRID 1949307노트

반응식

HRID 1949307 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH2:20][CH2:21][O:22][CH3:23])[CH:14]=3)=[CH:11][C:10]([C:24](O)=[O:25])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.ClC1C=C(N2C(C3C=CC=C(OCCO)C=3)=CC(C([N:51]3[CH2:55][C:54](=[O:56])[NH:53][CH2:52]3)=O)=N2)C=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH2:20][CH2:21][O:22][CH3:23])[CH:14]=3)=[CH:11][C:10]([C:24]([N:51]3[CH2:55][C:54](=[O:56])[NH:53][CH2:52]3)=[O:25])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 58277330HCID 58277330, 화합물HCID 58277360HCID 58277360, 화합물

생성물 1

HCID 58277274HCID 58277274, 화합물

실험 절차

The preparation of the title compound takes place starting from the compound of Example 117A in analogy to the synthesis of the compound of Example 23. In order to remove the 1,1′,1″-phosphoryltripyrrolidine the product is taken up in a little tetrahydrofuran, water is added to the mixture until a precipitate forms, the tetrahydrofuran is removed in vacuo, and the precipitate is collected by suction filtration, and dried under high vacuum. 10 mg (19% of theory) of the title compound are obtained.

후처리

  1. customIn order to remove the 1,1′,1″-phosphoryltripyrrolidine the product
  2. additionis added to the mixture until a precipitate forms
  3. customthe tetrahydrofuran is removed in vacuo
  4. filtrationthe precipitate is collected by suction filtration
  5. customdried under high vacuum

출처 및 근거

ORD 기록
ord-e6e004ac258d477c8b23942b08099281
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399682B2

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