Aic-292 → HCID 58277420, 화합물

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=3)=[CH:11][C:10]([C:20]([OH:22])=O)=[N:9]2)=[CH:4][CH:3]=1.ClC1C=C(N2C(C3C=C(F)C=C(Cl)C=3)=CC(C([N:46]3[CH2:50][C:49](=[O:51])[NH:48][CH2:47]3)=O)=N2)C=CC=1F>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=3)=[CH:11][C:10]([C:20]([N:46]3[CH2:50][C:49](=[O:51])[NH:48][CH2:47]3)=[O:22])=[N:9]2)=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 44230181Aic-292

HCID 58277349HCID 58277349, 화합물

생성물 1

HCID 58277420HCID 58277420, 화합물

실험 절차

The preparation of the title compound takes place starting from the compound of Example 105A in analogy to the synthesis of the compound of Example 1. 15 mg (39% of theory) of the title compound are obtained.

출처 및 근거

ORD 기록: ord-5b73096cb6cc4b8887022f90734bdf8b
출처 데이터셋: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08399682B2

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