Morpholine → N-(2-(4-(2-chlorophenyl)-4H-1,2,4-triazol-3-yl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-8-yl)-2-morpholinoacetamide
반응식
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:7]=[CH:8][C:9]2[C:15]3[S:16][C:17]([C:19]4[N:23]([C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=5[Cl:30])[CH:22]=[N:21][N:20]=4)=[CH:18][C:14]=3[CH2:13][CH2:12][O:11][C:10]=2[CH:31]=1)=[O:4].[NH:32]1[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1>>[Cl:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[N:23]1[CH:22]=[N:21][N:20]=[C:19]1[C:17]1[S:16][C:15]2[C:9]3[CH:8]=[CH:7][C:6]([NH:5][C:3](=[O:4])[CH2:2][N:32]4[CH2:37][CH2:36][O:35][CH2:34][CH2:33]4)=[CH:31][C:10]=3[O:11][CH2:12][CH2:13][C:14]=2[CH:18]=1참가 물질
3
실험 절차
Following the procedure in Example 147 for 237, 2-chloro-N-(2-(4-(2-chlorophenyl)-4H-1,2,4-triazol-3-yl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-8-yl)acetamide was reacted with morpholine to give 236. MS: (ESI+) 522.3
출처 및 근거
- ORD 기록
- ord-995f1bb74c8f41eb884e9042721f1cbe
- 출처 데이터셋
- uspto-grants-2013_03
- 특허 번호
- US08399690B2