4-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrile → 4-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzaldehyde

HRID 1949998노트

반응식

HRID 1949998 반응식
NC(C)(C)C[O:4]C1C=CC(C#N)=CC=1F.[CH3:16][N:17]([CH3:32])[C:18]([CH3:31])([CH3:30])[CH2:19][O:20][C:21]1[CH:28]=[CH:27][C:24]([C:25]#N)=[CH:23][C:22]=1[F:29]>>[CH3:16][N:17]([CH3:32])[C:18]([CH3:31])([CH3:30])[CH2:19][O:20][C:21]1[CH:28]=[CH:27][C:24]([CH:25]=[O:4])=[CH:23][C:22]=1[F:29]

참가 물질

3

반응물 2

HCID 230872344-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrileHCID 230874174-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzonitrile

생성물 1

HCID 230871524-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzaldehyde

실험 절차

Synthezised from 4-(2-amino-2-methylpropoxy)-3-fluorobenzonitrile according to an analogous synthetic method to Preparation Example 18, 4-(2-dimethylamino-2-methylpropoxy)-3-fluorobenzonitrile (1.4 g) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (965 mg).

후처리

  1. customwas used according to an analogous synthetic method to Preparation Example 16

출처 및 근거

ORD 기록
ord-e6cd3bba8fad4beb9fa314f7bd755977
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399520B2

반응 노트

불러오는 중…