Cyclopropylamine → [6-(2-Chloro-imidazol-1-yl)-pyrimidin-4-yl]-cyclopropyl-amine

HRID 19500노트

반응식

HRID 19500 반응식
Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH:12]=[CH:11][N:10]=[C:9]2[Cl:13])[N:5]=[CH:4][N:3]=1.[CH:14]1([NH2:17])[CH2:16][CH2:15]1>CO>[Cl:13][C:9]1[N:8]([C:6]2[N:5]=[CH:4][N:3]=[C:2]([NH:17][CH:14]3[CH2:16][CH2:15]3)[CH:7]=2)[CH:12]=[CH:11][N:10]=1

참가 물질

4

반응물 2

HCID 69828CyclopropylamineHCID 589730674-Chloro-6-(2-chloro-imidazol-1-yl)-pyrimidine

생성물 1

HCID 58973138[6-(2-Chloro-imidazol-1-yl)-pyrimidin-4-yl]-cyclopropyl-amine수율 90%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

4-Chloro-6-(2-chloro-imidazol-1-yl)-pyrimidine (0.85 g, 4 mmol) and cyclopropylamine (1.4 mL, 20 mmol) were mixed in 10 mL methanol and stirred at 50° C. for 12 hours. After reaction was complete, the solvent was removed by rotary evaporation. The crude product was washed with water and taken to dryness to give the title compound (0.84 g, 90%); 1H NMR 400 MHz (DMSO-d6) δ 8.45 (s, 1H), 8.17 (d, 1H), 7.75 (s, 1 H), 7.08 (s, 1H), 6.80 (d, 1H), 3.34 (s, 1H), 0.78 (br, 2H), 0.52 (br, 2H); MS m/z 236.4 (M+1).

후처리

  1. customAfter reaction
  2. customthe solvent was removed by rotary evaporation
  3. washThe crude product was washed with water

출처 및 근거

ORD 기록
ord-7639acae788645ac9f0a1c2194593ae7
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745437B2

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